WebJan 1, 2024 · Cisplatin treatment induces premature senescence in renal tubular cells in vitro and in vivo To evaluate whether cisplatin can induce senescence in renal tubular cells in vitro, NRK cells were incubated with cisplatin (20 μg/ml) for 6 h, and then incubated in complete medium for 24, 48, and 72 h. WebApr 25, 2014 · Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and …
Cisplatin nephrotoxicity: mechanisms and renoprotective …
WebAug 6, 2014 · Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors. A known complication of cisplatin administration is acute kidney injury (AKI). WebAug 24, 2024 · These renal injuries may cause delays and potentially cessation of cisplatin therapy and have long-term effects on renal function reserve. Thus, developing mechanism-based interventional strategies that minimize cisplatin-associated kidney injury without reducing efficacy would be of great benefit. switch en125
Cisplatin - The Internet Drug Index for prescription drugs ...
WebDec 17, 2024 · In cisplatin-induced acute kidney injury (AKI) or nephrotoxicity, autophagy is rapidly induced in renal tubular epithelial cells and acts as a cytoprotective mechanism for cell survival. Both mTOR and AMPK have been implicated in the regulation of autophagy in cisplatin-induced AKI. Webcisplatin (Rx) Brand and Other Names: Classes: Antineoplastics, Alkylating; Antineoplastics, Platinum Analog Print Dosing & Uses AdultPediatricGeriatric Dosage Forms & Strengths injectable... WebDec 12, 2024 · Cisplatin is mainly excreted through the kidneys and can induce nephrotoxicity through proximal tubular injury, by promoting oxidative stress via reactive oxygen species (ROS), inflammation, apoptosis, autophagy and vascular injury in … switchemu_v2