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Cisplatin and kidney

WebJan 1, 2024 · Cisplatin treatment induces premature senescence in renal tubular cells in vitro and in vivo To evaluate whether cisplatin can induce senescence in renal tubular cells in vitro, NRK cells were incubated with cisplatin (20 μg/ml) for 6 h, and then incubated in complete medium for 24, 48, and 72 h. WebApr 25, 2014 · Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and …

Cisplatin nephrotoxicity: mechanisms and renoprotective …

WebAug 6, 2014 · Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors. A known complication of cisplatin administration is acute kidney injury (AKI). WebAug 24, 2024 · These renal injuries may cause delays and potentially cessation of cisplatin therapy and have long-term effects on renal function reserve. Thus, developing mechanism-based interventional strategies that minimize cisplatin-associated kidney injury without reducing efficacy would be of great benefit. switch en125 https://serendipityoflitchfield.com

Cisplatin - The Internet Drug Index for prescription drugs ...

WebDec 17, 2024 · In cisplatin-induced acute kidney injury (AKI) or nephrotoxicity, autophagy is rapidly induced in renal tubular epithelial cells and acts as a cytoprotective mechanism for cell survival. Both mTOR and AMPK have been implicated in the regulation of autophagy in cisplatin-induced AKI. Webcisplatin (Rx) Brand and Other Names: Classes: Antineoplastics, Alkylating; Antineoplastics, Platinum Analog Print Dosing & Uses AdultPediatricGeriatric Dosage Forms & Strengths injectable... WebDec 12, 2024 · Cisplatin is mainly excreted through the kidneys and can induce nephrotoxicity through proximal tubular injury, by promoting oxidative stress via reactive oxygen species (ROS), inflammation, apoptosis, autophagy and vascular injury in … switchemu_v2

cisplatin and kidney dysfunction — Cancer Survivors Network

Category:Cisplatin nephrotoxicity as a model of chronic kidney disease

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Cisplatin and kidney

Nephrotoxicity as a Dose-Limiting Factor in a High-Dose Cisplatin …

WebTY - JOUR. T1 - Caught in the crossfire. T2 - cancer, cisplatin therapy, and kidney injury. AU - Humphreys, Benjamin D. PY - 2024/4/1. Y1 - 2024/4/1 WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 …

Cisplatin and kidney

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WebCisplatin is one of the most widely used and most potent chemotherapy drugs. However, side effects in normal tissues and organs, notably nephrotoxicity in the kidneys, limit the … WebOct 13, 2024 · Cisplatin is nephrotoxin that can cause both acute kidney injury and chronic kidney disease. Accumulation of cisplatin in renal tubular cells induces various intracellular stresses,...

Webwww.ncbi.nlm.nih.gov WebCisplatin is a potent antineoplastic agent derived from platinum and commonly used in the treatment of head and ... both water restrictions and sodium supplementation may be …

WebApr 14, 2024 · Among the changes potentially relevant are the differences in the content of pyridoxine and kynurenine between the two types of ABs, i.e., cisplatin-treated vs. UV light exposed-cells, both in ABs content ( Table 1 and Figure S1) and in the extracellular fluid ( Table 1 and Figure S2 ). WebMar 23, 2024 · Although optimization of dosing and inclusion of cisplatin as part of combination therapy has reduced the incidence of cisplatin-induced acute kidney injury (AKI), nephrotoxicity remains the dose-limiting side effect and is also associated with the risk of future chronic kidney disease (CKD) ( 2 ).

WebHas anyone had kidney damage after Cisplatin? Buzz has elevated Creatinine, BUN, and decreased GFR. All that means is his kidneys are showing signs of not functioning fully. …

WebOct 13, 2024 · Cisplatin is nephrotoxin that can cause both acute kidney injury and chronic kidney disease. Accumulation of cisplatin in renal tubular cells induces various … switch enabled teamingWebFeb 15, 2024 · Traditional chemotherapeutic drugs, such as cisplatin and doxorubicin, are commonly used to treat various cancers, including lung, bladder, and ovarian cancer 1, 2, 3, 4. However, severe side... switch enableWebRenal injury induced by cisplatin primarily occurs in proximal tubules, 1 where the tubular injury causes a decrease in the glomerular filtration rate. 2 Because of this decrease in … switch en 10 foisWebMar 29, 2024 · A study involving TLR4-deficient mice administered a toxic dose of cisplatin (20 mg/kg) to induce acute renal failure within 72 h and reported significantly reduced markers of inflammation, nephrotoxicity, and renal function and decreased renal injury and histological abnormalities . switch enable bluetoothWebCisplatin is mainly excreted through the kidneys. It becomes concentrated during excretion, and the concentration in renal tubular epithelial cells is much higher than that in the blood. In the... switch enabledWebNov 12, 2024 · Nephrotoxicity: cisplatin injection can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Consider dose reductions or alternative treatments in patients with renal impairment.Peripheral Neuropathy: cisplatin injection can cause dose-related peripheral neuropathy. switch enable commandWebAug 6, 2014 · Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and … switch en anglais