Ctgf in ssc

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August undefined, 2024

WebFeb 1, 2010 · Objective. Systemic sclerosis (SSc) is a life-threatening autoimmune disease characterized by chronic fibrosis of the skin and internal organs. Connective tissue growth factor (CTGF) is believed to be a primary mediator of chronic fibrosis. We assessed the possible association between 7 single-nucleotide polymorphisms (SNP) in the CTGF … WebJul 19, 2024 · Skin and lung fibrosis in systemic sclerosis (SSc) is driven by myofibroblasts, alpha-smooth muscle actin expressing cells. The number of myofibroblasts in SSc skin …

Assessment of disease outcome measures in systemic sclerosis

WebIn SSc, serum CTGF levels correlate with the extent of skin and pulmonary fibrosis. The expression of CTGF can be induced in normal fibroblasts by TGF-β, IL-4, and VEGF, whereas TNF and prostacylins block stimulation. ... Connective tissue growth factor (CTGF or CCN2) is a prototypic member of the CCN family of cytokines. The CCN family … WebFeb 1, 2010 · Objective. Systemic sclerosis (SSc) is a life-threatening autoimmune disease characterized by chronic fibrosis of the skin and internal organs. Connective tissue growth factor (CTGF) is believed to … how far is galena from chicago il

Connective tissue growth factor in tissue fibrosis - ResearchGate

WebDownload Table Association of the CTGF*-945C/G Dimorphism in Thai Healthy Controls and SSc Patients with their Clinical Manifestations and Laboratory Findings from publication: Lack of CTGF ... WebSerum connective tissue growth factor (CTGF) is reported to be a potential biomarker for the diagnosis of rheumatoid arthritis (RA). Our study aimed to investigate the prevalence … WebNov 23, 2024 · Connective tissue growth factor (CTGF) is an important mediator in fibrotic disease. Single nucleotide polymorphisms (SNPs) in CTGF have been found to be a ... hepatic fibrosis and SSc. An association of CTGF rs6918698GG (equals to the CC in our study) with susceptibility to SSc was found in a British and Asian cohort (see material … how far is gaithersburg md from germantown md

Connective tissue growth factor: growth factor, matricellular

230 Anti-fibrotic efficacy of phosphodiesterase-5 inhibitors on ...

WebApr 1, 2024 · Connective tissue growth factor (CTGF), a member of CCN family, ... Some studies have tried to analyze the relationship between CTGF and SSc deeply in the level of the gene. In the previous study, the polymorphism (G-945C) in the promoter of CTGF gene was tested. It was found that −945G allele was important for the susceptibility to SSc. WebJul 14, 2013 · Connective Tissue Growth Factor (CTGF), also known as CCN2, is another pleotropic growth factor that has emerged as an important mediator of normal and pathological tissue fibrotic responses [171–174] and has been suggested to play a crucial role in SSc tissue fibrosis. how far is gaithersburg md from jessup mdWebEnter the email address you signed up with and we'll email you a reset link. high adventure excavation

"WebNational Center for Biotechnology Information " - Ctgf in ssc

Ctgf in ssc

Down‐regulation of collagen and connective tissue growth factor ...

WebMar 3, 2024 · Objective: To examine the mechanism of collagen induction by connective tissue growth factor (CTGF), a profibrotic cytokine overexpressed in the skin of patients with systemic sclerosis (SSc). Methods: Dermal fibroblasts from 7 SSc patients and 7 matched healthy adult donors were stimulated with CTGF in the presence or absence of … WebJul 20, 2024 · Systemic sclerosis (SSc) is a rheumatic disease with a high case mortality at present 1.This high mortality rate is driving continued intense interest in developing a deeper understanding of SSc ...

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Web结缔组织生长因子在硬皮病患者皮肤组织上的表达研究.pdf WebThe serum concentration of connective tissue growth factor (CTGF) in patients with RA (n = 39), SLE and SS (n = 15) and normal healthy controls (n = 50) were measured using a sandwich ELISA ...

WebJul 1, 2024 · 1. Introduction. Spermatogenesis is a precisely regulated program that produces sperm from the spermatogonial stem cell (SSC) [].In rodents, spermatogonia can be mainly divided into two subpopulations: the undifferentiated spermatogonia consisting of A-single (A s), A-paired (A pr) and A-aligned (A al) and the differentiating spermatogonia … WebTGF-β, Thrombin and CTGF in SSc Lung Fibrosis. The presence of myofibroblasts has been extensively documented in active fibrotic …

WebSep 10, 2008 · Connective tissue growth factor (CTGF), also know as CCN2, is a small cyteine-rich secreted multi-modular protein, ... Several approaches have been employed for antagonizing, blocking or inhibiting CTGF activity. In the context of SSc-associated lung disease, hepatocyte growth factor has been shown to down-regulate CTGF expression … WebFibrotic diseases such as scleroderma (systemic sclerosis, SSc) are characterized by an excessive production of extracellular matrix and profibrotic proteins such as connective tissue growth factor (CTGF). …

WebConnective Tissue Growth Factor/CCN2. CTGF is a cysteine-rich 40 kDa matricellular growth factor implicated in angiogenesis, wound healing, and development. Although it is …

WebUnited States » Georgia » Fulton County » Atlanta ». Professional & Other Places » Office. Make sure your information is up to date. Plus use our free tools to find new … how far is gaithersburg md from meWeb817-222-5966 (FAX) Western Service Center. 2200 S. 216th St. Des Moines, WA 98198-6547. 206-231-2420. The role of the Service Center is to provide shared services which … how far is galena from chicagoWebJun 13, 2024 · Although the involvement of connective tissue growth factor (CTGF/CCN2) has been well-documented in SSc fibrosis, the therapeutic potential of targeting CTGF in … high adventure elk ranchWebA drawback to using Col1a2-CTGF mouse to study human SSc is perhaps that SSc onset often occurs later in life, and when the CTGF gene is upregulated constitutively in Col1a2-CTGF mice, profound changes are likely to have already occurred from birth given the role of CTGF in development (Canalis et al., 2010; Nagashima et al., 2011). how far is galaxy cluster smacs 0723WebMay 8, 2011 · Connective tissue growth factor (CTGF/CCN-2) is a key peptide mediating organ fibrosis [1-3]. Fonseca et al. identified a single nucleotide polymorphism (SNP) at position -945 upstream from the transcription initiation site of the CTGF gene (-945GC) overrepresented in patients with systemic sclerosis (SSc) and associated with a higher … how far is galena from milwaukeeWebJan 3, 2024 · Abstract Serum connective tissue growth factor (CTGF) is reported to be a potential biomarker for the diagnosis of rheumatoid arthritis (RA). Our study aimed to investigate the prevalence of serum CTGF and the association with the clinical features in RA patients. Serum samples were obtained from 180 patients with RA, 168 patients with … how far is galenaWebAlthough the precise molecular mechanisms driving fibrosis remain elusive, TGF-beta and connective tissue growth factor (CTGF), are considered key mediators. CTGF is over-expressed in lesional tissue and enhanced levels in the circulation are an indicator of disease extent and severity. ... In animal models of SSc, neutralization of CTGF with ... how far is galena from me