Ctsk macrophage
WebWe previously found increased Ctsk expression and secretion in Npc1 / macrophages and increased elastase activity in aortic homogenates of Apoe /, Npc1 / mice.5 To confirm in vivo relevance, we used an affinity-purified antibody18 and found strong CATK immunostaining in the macrophage-rich regions of atherosclerotic plaques in Apoe /, Npc1 mice WebSep 2, 2024 · However, at 34 hphs, the motility of differentiating macrophages became reduced as they started to express ctsk:GFP, while undifferentiated macrophages remained highly mobile (Supplementary Fig. S1B; Movie S4). This suggests that the reduction of macrophage dynamics is a prerequisite for osteoclast differentiation, …
Ctsk macrophage
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WebJun 5, 2024 · CTSK and MMP9 transcripts have also been found to be part of a macrophage multinucleation network in the rat (Kang et al., 2014). In addition, MGCs have been shown to express TRAP ( Park et al., 2012 ), suggesting that phenotypic markers of cell multinucleation are shared by MGCs and osteoclasts. WebApr 14, 2024 · Significant upregulation of several known OC genes was established in the OC group, such as CTSK, DC-STAMP, ACP5, MMP9, ATPV0D2, and ITGB3, which gives confidence in the OC-like nature of the cell culture model. In addition, several genes identified as upregulated in the OCs have genetic evidence for association with bone traits.
WebMay 7, 2024 · After knockout of Ctsk, the gene encoding Ctsk, the outcomes of Ctsk +/+ and Ctsk −/− mice were compared 24 h after rtPA-treated cerebral ischaemia with … WebMay 7, 2024 · After knockout of Ctsk, the gene encoding Ctsk, the outcomes of Ctsk +/+ and Ctsk −/− mice were compared 24 h after rtPA-treated cerebral ischaemia with respect to HT severity, neurological deficits, brain oedema, infarct volume, number of apoptotic neurons and activated microglia/macrophage, blood–brain barrier integrity, vascular ...
WebCtsk, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more ... Product Images from "Macrophages-derived exosomes modulates wear particle-induced osteolysis via miR-3470b targeting TAB3/NF-κB signaling" WebApr 13, 2024 · On day 5, the expression of nuclear factor of activated T cell 1 (NFATc1), acid phosphatase 5 (Acp5), cathepsin K (Ctsk) and matrix metalloprotein 9 (Mmp9), marker genes of osteoclast activity ...
WebNov 17, 2024 · Introduction. Osteoclasts originate from the monocyte/macrophage lineage and are unique multinucleated giant cells capable of bone resorption. They play …
WebMay 19, 2024 · In humans, phagosomal CtsK activity was reduced in COPD lung macrophages and non-COPD lung macrophages exposed to cigarette smoke extract. Taken together, this study provides a comprehensive map of how peritoneal, lung and brain tissue environment shapes phagosomal composition, revealing CtsK as a key molecular … diary of mad housewifeWebJan 16, 2013 · Mx1-Cre–induced deletion of Ctsk in hematopoietic cells and osteoclasts increased osteoclast differentiation from BM macrophages (BMMs) (Figure 6, ... cities: skylines wikiWebNov 17, 2024 · Introduction. Osteoclasts originate from the monocyte/macrophage lineage and are unique multinucleated giant cells capable of bone resorption. They play indispensable roles in regulating bone remodeling and maintaining bone mass [].Increased or decreased osteoclast development or function results in an imbalance between bone … cities skylines why is everyone sickWebJul 13, 2024 · Cathepsin K (Ctsk) is a cysteine protease of the papain superfamily initially identified in differentiated osteoclasts; it plays a critical role in degrading the bone matrix. However, subsequent in vivo and in vitro studies based on animal models elucidate novel subpopulations of Ctsk-expressing cells, which display markers and properties of … diary of mary chesnutWebMar 31, 2024 · Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and ... matrix metallopeptidase 9 (MMP9) and cathepsin K (CTSK). … cities skylines where to put district stylesWebRepresentative images of Ctsk-Cre/mTmG macrophages and osteoclasts captured on the indicated days (Day 0 is the time RANKL was first added to osteoclast cultures). Red and green channels supposedly correspond to the indicated fluorophores. The scale bar corresponds to 100 μm and applies to all images. cities skylines which dlc to getWeb1 day ago · RAW264.7 macrophages, used as a preosteoclast model, were incubated in 89% DMEM medium until they reached 80% confluence, and were then cocultured for 10 days with T cells extracted from the ... diary of me