Web方法. 回顾性分析2016年2月至2024年1月上海市肺科医院与复旦大学附属肿瘤医院确诊的5例肺gct的临床资料、病理形态学特征及免疫表型特点,并复习相关文献。 WebA weak cytoplasmic staining reaction in cells with a strong nuclear staining reaction was accepted. Participation Number of laboratories registered for SOX10, run 55 211 Number of laboratories returning slides 204 (97%) Results 204 laboratories participated in this assessment. 181 (89%) achieved a sufficient mark (optimal or good).
Did you know?
WebSOX10 and/or S100 protein immunopositivity in conjunction with rearrangement of the PLAG1 gene assisted in reclassification of a subset of oncocytomas as oncocytic variants of PA and ME. Therefore, we recommend to include S100 protein and SOX10 IHC when diagnosing tumors with predominantly oncocytoma-like differentiation. WebIn ARM, cytoplasmic SOX10 was co-expressed with neuronal antigens in ~57% of submucosal and myenteric neurons, vs. ~3% in control. Furthermore, intrinsic gut neurons in ARM specimens co-expressed PLP1 (18%) and CDH19 (18%); however, neuronal co-expression of PLP1 and CDH19 was rarely (<2%) observed in controls.
WebDec 3, 2024 · SOX10, located at 22q13.1, has five transcripts (splice variants), 67 orthologs, and 16 paralogs. As a nucleocytoplasmic shuttle protein, SOX10 is of great significance to the development of the neural crest, the peripheral nervous system, and melanocytes ( Castillo and Sanchez-Cespedes, 2012 ). WebApr 1, 2024 · We have previously shown that SOX10 is expressed in one hundred percent of primary human melanoma samples and that its expression is crucial for melanoma initiation, but also maintenance of...
WebAug 11, 2015 · SOX10 was negative in 10 cases of ITACs and 2 cases of non-ITACs, and positive in all other adenocarcinomas. The sensitivity of CK7-, CK20+, SOX10- and CDX2+ in primary ITACs of the sinonasal tract were 70.0%, 90.0%, 100%, 100%, respectively, and the specificity were 100%, 96.8%, 93.5%, 100%, respectively. Conclusions: WebSep 1, 2024 · Ten cases originally diagnosed as OC, and 1 low-grade uncertain oncocytic tumor (11/74) revealed nuclear-cytoplasmic and/or nuclear positivity for S100 protein and/or SOX10, respectively. Fusion transcripts CHCHD7-PLAG1 and GEM-PLAG1 were found in 2 cases (1 fusion in each), and these were confirmed by RT-PCR and PLAG1 …
WebSox10 shuttles between the nucleus and the cytoplasm. Since Sox10 can be found in the nucleus as well as in the cytoplasm, we addressed the question whether Sox10 has nu- cleocytoplasmic shuttling ...
WebSox10 shuttles between the nucleus and the cytoplasm. Since Sox10 can be found in the nucleus as well as in the cytoplasm, we addressed the question whether Sox10 has nucleocytoplasmic shuttling activity. An interspecies heterokaryon analysis was performed as originally described by Pinol-Roma and Dreyfuss . pc game hdWebApr 4, 2024 · Orthologous to human SOX10 (SRY-box transcription factor 10). [provided by Alliance of Genome Resources, Apr 2024] Sox10 SRY (sex determining region Y)-box 10 [ (house mouse)] Gene ID: 20665, updated on 4-Apr-2024. Summary. ... and nervous system development. Located in cytoplasm and nucleus. Is extrinsic component of … pc game heavenWebSOX10. −: − ± ... The cytoplasm is usually amphophilic and granular due to their secretory content. MTCs routinely express neuroendocrine markers as well as signs of thyroid differentiation (TTF1), whereas monoclonal PAX8 expression is lacking, as is thyroglobulin (the latter a consequence of the non-follicular cell origin). ... pc game headphonesWebMar 21, 2024 · SOX10 (SRY-Box Transcription Factor 10) is a Protein Coding gene. Diseases associated with SOX10 include Peripheral Demyelinating Neuropathy, Central … pc game heatWebNuclear and cytoplasmic Expression in Normal Tissues [] This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. In the central nervous system, … pc game harry potterWebIn accord with its function as transcription factor, Sox10 contains two nuclear localization signals and is most frequently detected in the nucleus. In this study, we report that … pc game heavy gearWebFeb 6, 2024 · The relocalization of ectopic Neurog2 from the nucleus to the cytoplasm suggests the possibility that overexpression of Sox10 promotes ubiquitination of Neurog2, which could occur in both compartments as evidenced by another short-lived bHLH transcription factor, MyoD ( 26 ). scrollsaws on youtube