Dynamo mapping vector field of single cells
WebInclusive model of expression dynamics with metabolic labeling based scRNA-seq / multiomics, vector field reconstruction and differential geometry analyses - dynamo-release-Mapping-Vector-Field-of-... WebDynamo. : Mapping Vector Field of Single Cells. Single-cell (sc)RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution. Fully exploiting these …
Dynamo mapping vector field of single cells
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WebDynamo: Mapping Transcriptomic Vector Fields of Single Cells. Inclusive model of expression dynamics with metabolic labeling based scRNA-seq / multiomics, vector field reconstruction, potential landscape mapping, differential geometry analyses, and most probably paths / in silico perturbation predictions. Installation - Ten minutes to dynamo - … WebFeb 2, 2024 · Our analytical framework, dynamo, consists of four integral stages: 1) estimation of genome-wide kinetic rate constants and velocity vectors, 2) reconstruction of single-cell vector field functions with the resultant cell state and velocity samples, 3) in-depth analyses leveraging various differential geometry analyses, and 4) predictions of ...
http://dynamo-readthedocs.readthedocs.io/ WebFeb 18, 2024 · To enable such temporal analysis from multimodal single-cell experiments, we introduce an extension of the RNA velocity method that leverages estimates of unprocessed transcript and protein abundances to extrapolate cell states. ... Wang L, Yuan R, et al. Mapping Vector Field of Single Cells. Biorxiv. 2024;9:696724. Google Scholar …
WebFeb 2, 2024 · Our analytical framework, dynamo, consists of four integral stages: 1) estimation of genome-wide kinetic rate constants and velocity vectors, 2) reconstruction … WebFeb 2, 2024 · Researchers at the Whitehead Institute for Biomedical Research and other centers describe a computational approach called dynamo, which they used to retrace RNA velocity and single-cell transcriptomic "vector fields," and regulatory features from time-resolved single-cell RNA sequence data. "This framework represents a notable advance …
WebLeveraging the least-action-path method, dynamo accurately predicts drivers of numerous hematopoietic transitions. Finally, in silico perturbations predict cell-fate diversions induced by gene perturbations. Dynamo, thus, represents an important step in advancing quantitative and predictive theories of cell-state transitions.
WebJul 9, 2024 · Here, we introduce dynamo, an analytical framework that reconciles intrinsic splicing and labeling kinetics to estimate absolute RNA velocities, reconstructs velocity … normal and abnormal prepuceWebLeveraging the least-action-path method, dynamo accurately predicts drivers of numerous hematopoietic transitions. Finally, in silico perturbations predict cell-fate diversions … normal and abnormal memory changesWebInclusive model of expression dynamics with metabolic labeling based scRNA-seq / multiomics, vector field reconstruction and differential geometry analyses - GitHub - KBRI-Biology-Experiment-Comput... normal and abnormal rabbit behaviourWebDynamo: Mapping Vector Field of Single Cells. Single-cell RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented … how to remove odors from clothes dryerWeb•Vector fields reveal the timing and mechanisms of human hematopoiesis •Dynamo allows cell-state transition path and in silico perturbation predictions . Summary. Single-cell … normal anatomy of the placentahttp://dynamo-readthedocs.readthedocs.io/ how to remove odor from vinyl furnitureWebFeb 9, 2024 · Here, we introduce dynamo, an analytical framework that reconciles intrinsic splicing and labeling kinetics to estimate absolute RNA velocities, reconstructs velocity … how to remove odors from silicone