Gdf15 monoclonal antibody
WebNov 1, 2011 · Growth differentiation factor 15 (GDF15), which is structurally similar to TGF beta, has been reported to stimulate phosphorylation of HER2. We tested the … Resistance to the anti-HER2 monoclonal antibody trastuzumab is a major problem in the treatment of HER2-overexpressing metastatic breast cancer. WebGet better batch-to-batch reproducibility with a recombinant antibody. Anti-GDF15 antibody [EPR19939] (ab206414) Research with confidence – consistent and reproducible results with every batch. Long-term and scalable supply – powered by recombinant technology for fast production. Success from the first experiment – confirmed specificity ...
Gdf15 monoclonal antibody
Did you know?
WebGrowth differentiation factor 15 (GDF15) is a member of the transforming growth factor-β (TGF-β) cytokine family and an inflammation-associated protein. Here, we investigated the role of GDF15 in murine anti-glomerular basement membrane (GBM) glomerulonephritis. ... However, an anti-CD8 monoclonal antibody therapy was effective in both the ... WebDec 1, 2024 · Mice with tumors overexpressing GDF15 ate less and lost a substantial amount of adipose mass; in return, injection of recombinant GDF15 reproduced the weight loss. This effect was specific: a single injection of a monoclonal antibody to human GDF15 rapidly reversed the weight loss without having any effect on tumor size.
WebJan 10, 2024 · GDF-15 Antibody (G-5) is an IgG 1 κ mouse monoclonal GDF-15 antibody (also designated GDF15 antibody, or MIC1 antibody) suitable for the detection of the GDF-15 protein of human origin by WB, … WebApr 12, 2024 · DKN-01 is being developed in patients with esophagogastric, gynecologic, and colorectal cancers. FL-301, a humanized monoclonal antibody targeting Claudin18.2, is being developed in patients with gastric and pancreatic cancer. Leap also has preclinical antibody programs targeting Claudin18.2/CD137 and GDF15.
WebJul 1, 2024 · Furthermore blockade of GDF-15 by AZD8853, an anti-GDF15 monoclonal antibody, can restore these activities in vitro. Tumors derived from GDF15 knock-out syngeneic cell lines, Renca and MC-38, show 2-3 fold increases in T cells and activated DCs in the TME as compared to tumors derived from isogeneic parental cells. Treatment … WebJan 30, 2014 · Growth differentiation factor 15 (GDF15) is aberrantly secreted by bone marrow stromal cells (BMSCs) in MM. We found that GDF15 is produced by BMSCs after direct contact with plasma cells and enhances the tumor-initiating potential and self-renewal of MM cells in a protein kinase B- and SRY (sex-determining region Y)-box–dependent …
WebGrowth differentiation factor 15 (GDF15), also known as macrophage inhibitory cytokine-1 (MIC-1), is a protein of the transforming growth factor beta (TGFb) superfamily that regulates inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF15 is a stress-induced cytokine and associated with hypoxia ...
WebThe current GDF15 antibodies do not distinguish between the monomeric and dimeric GDF15. Therefore, additional investigations need to be conducted to elucidate the role of GDF15 in cancer. Table 1. Summary of GDF15’s role in cancer. Each reference includes functional study of GDF15 either in vivo or in vitro. Anti, anti-proliferation activity ... t12 fluorescent light stripWebGross cystic disease of the breast is benign premenopausal disorder in which cysts are a predominant pathological lesion. These cysts appear to be formed from excessive apocrine cystic secretions. This fluid is composed … t12 fluorescent tubes 25wWebMonoclonal Anti-GDF15 antibody produced in mouse (MIC-1 ); Prestige Antibodies Powered by Atlas Antibodies, monoclonal CL0328, purified immunoglobulin, buffered aqueous … t12 fracture treatment nhsWebMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human GDF15/MIC1 protein. Background Macrophage inhibitory cytokine-1 (Mic-1), also termed GDF15 (1), PTGF-β (2), PLAB (3), PDF (4), and NAG-1 (5), is a divergent member of the transforming growth … t12 fracture physical therapyWebThese antibodies target GDF15 in Human, Mouse, Rat and Non-human primate samples. Our GDF15 polyclonal and monoclonal antibodies are developed in Rabbit, Mouse, Goat, Rat and Sheep. These antibodies have been verified by Cell treatment, Relative … t12 fluorescent single tubeWebApr 9, 2024 · The sections were incubated with FoxO1 and klotho antibodies (1:200) for 60 min at room temperature, then rinsed with PBS for 15 min, and each section was incubated with 150 μL of 1× PBS diluted fluorescent secondary antibody (Nakasugi Jinqiao ZF0311) for 60 min at room temperature. ... Growth differentiation factor 15 (GDF15) ... t12 fluorescent recessed bulbsWebGDF15 Antibody (MA5-31346) in ICC/IF. Immunocytochemistry-Immunofluorescence analysis of GDF15 in A549 cells using GDF15 … t12 investment