WebFeb 14, 2024 · Additionally, TF-1 cells harbouring either the CALRdel52 or CALRdel61 mutations but lacking TpoR were unaffected when treated with 4D7 (Fig EV2B and C). Interestingly, MARIMO cells also did not show inhibition with 4D7, consistent with CALR no longer acting as a driver mutation in this NRAS mutant cell line (Han et al, 2024) (Fig … WebJul 22, 2016 · Finally, STAT1, STAT3, and STAT5 were not phosphorylated in the MARIMO cell line derived from a patient with ET harboring a CALR mutation (Kollmann et al. 2015 ). Taken together, these findings suggest the possibility that a lack of STAT3 phosphorylation may be related to the lower NAP score observed in MPN patients with CALR mutations.
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WebJan 1, 2001 · A novel myeloid leukemia cell line, Marimo, was established from bone marrow cells of a patient with secondary acute myeloid leukemia (AML) that had … WebOct 21, 2024 · MARIMO cells, the only human cell line to date harboring mutated CALR ( Kollmann et al., 2015 ), was reported to carry an additional NRAS Q61K mutation, which is responsible for transformation independent from mutant CALR ( Han et al., 2024 ). Therefore, the validity of this cell line as a model for CALR mutation analysis is … brettspielwelt thurn und taxis
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WebThe first name Marimo has been assigned to: 100.00% to boys. 0.00% to girls. The country where the first name Marimo is the most common is: Germany. This first name is on … WebEight AML cell lines (U937, THP-1, SKM-1, SKK-1, SKNO-1, HL-60, MARIMO and KO52) were treated with GO and PP242. The cytotoxic effect of GO was enhanced by concurrent treatment with a non-cytotoxic concentration (500 nM) of PP242 in most cell lines, except MARIMO and KO52 cells. WebThe CALR mutation in human cell line MARIMO is shown below the DNA sequence. Solid red line and capillary sequencing image show a heterozygous 61-bp deletion (c.1099_1159del; L367fs*43) in country clipper westfield ma