Phospholipidosis liver
WebNov 29, 2024 · The long term effects of phospholipidosis are unknown. One cat in the 3X group had an enlarged thyroid/parathyroid gland found at necropsy. Higher liver weights occurred in cats in the 3X and 5X group that correlated with … WebNov 1, 2015 · Its hepatic toxicity is similar to amiodarone, histologically mimicking alcoholic steatohepatitis, associated with phospholipidosis. 111, 112 Pharmacologically, the drug impairs hepatic liver metabolism similarly to amiodarone, concentrating in the mitochondria, uncouples oxidative phosphorylation and inhibits ß-oxidation of fatty acids.
Phospholipidosis liver
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WebJan 16, 2015 · Amiodarone-induced cirrhosis (AIC) is a rare and challenging diagnosis, and established mortality rates for AIC can be as high as 60% at 5 months. 1 The most common reported symptoms of AIC are generalized weakness, abdominal pain, and distention, with nearly one-quarter of patients presenting with some degree of abdominal distention or … WebApr 23, 2024 · Drug-induced phospholipidosis (PL) is a storage disorder caused by the formation of phospholipid-drug complexes in lysosomes. Because of the diversity of PL between species, human cell-based assays have been …
Webation. For the hepatic phospholipidosis samples, archival paraffin-embedded tissue blocks were utilized from a 7-day dose-range finding study of an experimental compound that had cationic amphiphilic properties and caused dis-seminated phospholipidosis in dosed-rats as observed by light microscopic examination and confirmed via electron ... WebApr 6, 2024 · They serve as a repository of various lipids and are associated with many cellular metabolic processes, including energy storage, membrane synthesis, and protein homeostasis. LDs are prominent in a variety of diseases related to lipid regulation, including obesity, fatty liver disease, diabetes, and atherosclerosis.
WebApr 27, 2009 · About 18 months after taking amiodarone, liver enzymes were noted to have increased and computed tomographic (CT) scanning of the abdomen showed a significant increase in the density of the liver without contrast medium, compared to that of the spleen and surrounding tissues (113 Hounsfield units (H), normal range of the liver is about … WebJan 20, 2024 · For example, excess storage of these molecules in nerve tissues can cause developmental disabilities, accumulation in the tissues of the spleen and liver can cause poor functioning of these vital organs, and excess storage in the bone marrow can damage bones, leading to skeletal deformities.
WebJun 15, 2008 · Abstract. We have constructed a large-scale transcriptome database of rat liver treated with various drugs. In an effort to identify a biomarker for diagnosis of hepatic phospholipidosis, we extracted 78 probe sets of rat hepatic genes from data of 5 drugs, amiodarone, amitriptyline, clomipramine, imipramine, and ketoconazole, which actually …
WebMar 1, 2016 · National Center for Biotechnology Information in a child\\u0027s pathWebApr 5, 2013 · We present the first description of amiodarone toxicity in the liver without phospholipidosis or steatosis. In doing so, we will review the various effects of amiodarone toxicity in various organs. The patient is a young adult who had cardiac reconstruction as a child for transposition of the great vessels. A needle biopsy was taken due to elevated … dutch rotterdam shipWebJun 29, 2012 · The liver plays a key role in fat metabolism, and excessive lipid accumulation in liver cells is characterised by a large spectrum of lesions, e.g., steatosis and phospholipidosis. dutch room isabella stewart gardner museumWebPhospholipidosis is a lysosomal storage disorder characterized by the excess accumulation of phospholipids in tissues. [1] [2] [3] Certain cases may be triggered by medications. [4] … dutch rowboatWebPhospholipidosis is characterized by the formation of intra-cytoplasmic lysosomal vacuoles containing whorls of material derivedfrom cellmembrane. The most commonlyaffectedcell types include monocytes, histiocytes of lymphoreticular organs, and hepatocytes. Phospholipidosis in the brain and peripheral ganglia is unusual and has been reported ... dutch routes train simulatorWebOct 9, 2006 · Essentially, drug-induced phospholipidosis is characterized by phospholipid accumulation in affected tissue of which lung, liver, brain, kidney, cornea and others have … in a child\u0027s pathWebOct 1, 2014 · @article{osti_22439848, title = {Dysregulation of protein degradation pathways may mediate the liver injury and phospholipidosis associated with a cationic amphiphilic antibiotic drug}, author = {Mosedale, Merrie and Wu, Hong and Kurtz, C. Lisa and Schmidt, Stephen P. and Adkins, Karissa and Harrill, Alison H. and University of Arkansas for … in a childishly bad tempered way