Sialyl-lewis x
WebJun 3, 2024 · We also provide evidence that P-selectin is a key molecule on the peritoneal mesothelium that mediates the binding through a unique sialyl-Lewis x (sLe x) containing … WebApr 8, 2024 · In addition, sialyl Lewis X and sialyl Lewis a are also known to be the ligands of selectins that are a family of cell-adhesion molecules expressed on endothelial cells, leukocytes and platelets.
Sialyl-lewis x
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WebIt also recognizes Sialyl Lewis X with long carbohydrate attachments (Sialyl Lewis X-i). These antigens are expressed on human granulocytes, monocytes, small subsets of … WebSialyl-Lewis x (s-Le x)-bearing species have been selected from plasma with the monoclonal antibody CHO-131.This antibody selects s-Le x antigen at points of branching in which the …
WebSialyl-Lewis X. SLeX is a key recognition determinant for selectins that allow endothelial cells to recruit lymphocytes to roll on the endothelium prior to extravasation into tissues. … WebWe find that beads coated with the saccharides sialyl Lewis (x) (sLe (x)), sialyl Lewis (a) (sLe (a)), and sulfated Lewis (x) (HSO (3)Le (x) support rolling adhesion on P-selectin …
WebStructures of sialyl Lewis x (sLe x) and sialyl Lewis a (sLe a). Selectins bind to glycans with a terminal tetrasaccharide structure known as sialyl Lewis x/a. The core of the terminal tetrasaccharide is a disaccharide of galactose linked to N-acetylglucosamine (GlcNAc), either in α1,4 (sLe x) or α1,3 (sLe a) linkage. Sialyl Lewis (sLeX), also known as cluster of differentiation 15s (CD15s) or stage-specific embryonic antigen 1 (SSEA-1), is a tetrasaccharide carbohydrate which is usually attached to O-glycans on the surface of cells. It is known to play a vital role in cell-to-cell recognition processes. It is also the means by which … See more Sialyl-Lewis X is a tetrasaccharide composed of a sialic acid, fucose and an N-acetyllactosamine. Its systematic name is 5-acetylneuraminyl-(2-3)-galactosyl-(1-4)-(fucopyranosyl-(1-3))-N-acetylglucosamine (Neu5Acα2-3Galβ1 … See more Leukocyte homing Sialyl-Lewis is important in leukocyte tethering and rolling. Leukocytes move through the blood stream and then tether themselves to the … See more The term Lewis in its name comes from the name of a family of people who suffered from a red blood cell incompatibility. The studies done on these individuals' red … See more Leukocyte adhesion deficiency Defective synthesis of the sialyl Lewis antigen results in immunodeficiency (leukocyte adhesion deficiency type 2). Defective synthesis can be caused by the loss of fucosyltransferase, impairing the glycosylation of the … See more • CA19-9 (Sialyl-Lewis A) See more • Chen, G.-Y.; Osada, H.; Santamaria-Babi, L. F.; Kannagi, R. (7 November 2006). "Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes" See more
WebJan 1, 1995 · Ligand Recognition by E- and P-Selectin: Chemoenzymatic Synthesis and Inhibitory Activity of Bivalent Sialyl Lewis x Derivatives and Sialyl Lewis x Carboxylic Acids. The Journal of Organic Chemistry 1998 , 63 (15) , 5137-5143.
WebHigh amounts of sialyl Lewis(a) are present in human adenocarcinomas of the colon, pancreas and stomach. A growing amount of data suggests that this carbohydrate … how to shut down outlook when frozenWebThe 100 synthetic glycans featured in the Glycan Array 100 are the most frequently identified structures showing important binding function in the literature. For example, influenza virus binds to a variety of sialosides with a serotype-specific pattern. 7-9 Galectins, which are involved in apoptosis, cell adhesion and T-cell activation ... noughts and crosses viewing figuresWebJun 11, 2004 · Divergent syntheses of sulfated sialyl Lewis X oligosaccharides corresponding to the core 1 and core 6 branches of the l-selectin ligand are reported. These synthetic targets incorporate a selectively protected serine residue at the reducing terminus, providing a functional handle for further conjugation. how to shut down onedrive windows 10WebJun 6, 2024 · The sialyl Lewis X (SLe x) antigen encoded by the FUT7 gene is the ligand of endotheliam-selectin (E-selectin).The combination of SLe x antigen and E-selectin represents an important way for malignant tumor metastasis. In the present study, the effect of the SLe x-binding DNA aptamer on the adhesion and metastasis of hepatocellular … how to shut down parallels virtual machineWebSialyl Lewis x, Sodium Salt. Synonym(s): Sialyl Lewis x, Sodium Salt. Empirical Formula (Hill Notation): C 31 H 51 N 2 NaO 23. CAS No.: 98603-84-0. Molecular Weight: 842.73. … noughts and crosses warm upWebAug 15, 1995 · After removal of sialic acids, most of the mucins rich in sialyl-Lewis(a) and sialyl-Lewis(x) oligosaccharides no longer bound to a DEAE-cellulose column at pH 8.0. These results indicate that at least part of the sialyl-Lewis(a) and sialyl-Lewis(x) in SW1990 cells is associated with the MUC1 polypeptide. noughts and crosses vs googleWebJun 8, 2010 · For example, sialyl-Lewis x (sLe x) antigens are the ligands for selectins and are involved in the recruitment of leukocytes to lymphoid tissues and inflammation sites . Glycan structures depend on the cell type, developmental stage and cell differentiation, and are modified in many pathologic states including cancers. noughts and crosses wall game